In automated computer-based diagnosis systems, falsely determining that a case is normal is much more serious than falsely determining that the case is abnormal, especially if the system is being used for triage of patients. This is an example where false positives and false negatives are not equally bad. In this paper, the authors solve the problem proposing a new method: Risk Area SVM (RA-SVM).
The solution introduces a second classifier, which analyzes the k nearest neighbors (k-NN) within a defined risk area and classifies the data in this region as positive only if all its k-nearest neighbors are also positive. The authors compare the solution against the state-of-the-art methods for low false positive classification using 33 standard datasets. The obtained results demonstrate that RA-SVM has better performance in the vast majority of the cases.
Daniel Moraes, Jacques Wainer, Anderson Rocha, Low false positive learning with support vector machines, Journal of Visual Communication and Image Representation, Volume 38, July 2016, Pages 340-350, ISSN 1047-3203, doi:10.1016/j.jvcir.2016.03.007.